Promising Malaria Drug Has a Striking Drawback: Blue Urine

Promising Malaria Drug Has a Striking Drawback: Blue Urine


An Anopheles mosquito, which can carry malaria, in Mali during an experiment. A treatment in West Africa has been found to be effective against malaria but happens also to turn a patient’s urine blue.

Fabien Beilhe

Tests in West Africa have found that a safe drug long used to treat urinary tract infections is also effective against malaria. But the medication has one disadvantage: it turns urine a vivid blue.

“This is something we need to solve, because it could stop people from using it,” said Teun Bousema, a microbiologist at Radboud University Medical Center in the Netherlands and an author of the study, which was published Tuesday in The Lancet Infectious Diseases.

Modern malaria treatments, based on the drug artemisinin, are still effective in Africa and save hundreds of thousands of lives each year. But scientists fear the parasites will develop resistance, as they have in Southeast Asia, and are seeking ways to kill them faster using cocktails of several drugs.

Methylene blue, a dye used to stain tissues viewed under a microscope, can be taken by tablet or injection, and is sometimes used to treat urethral infections and a hemoglobin disorder.

But the dye also kills the malaria parasites in the gametocyte stage, the point at which mosquitoes pick it up from human blood and pass it on to new victims.

Most malaria drugs do not target gametocytes, meaning that someone may still spread the disease for a week or more after treatment.

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